Protein Details: Acid-sensing ion channel 1C
Protein ID
ICDB_Pro_1132
Protein Name
Acid-sensing ion channel 1C
Gene Name
asic1c; accn2c
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Length
529 amino acids
AlphaFoldDB
AF-Q708S6-F1-model_v4.pdb
Function
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions; but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.
Sequence
MTAMKGDSEDSIESMRPSNLQVFANNSTLHGMSHIFAYGHMTFRRFLWTLSFMGSLGLLMYVCMDRVYYYFEFPHVTKLDEVAAPNLTFPAVTFCNLNEFRFSKITKNDLYHVGELLALLNENYQIANPHLADPEVLTLLKEKASFNGFKPKQFNMTDFYNRTGHDINEMLLQCSFRGEECFPLNFTTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLDIQQDEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLLYLPPPWGDCRSAPMDSEYFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPEQYKDCADPALDFLVEKDNDYCVCDTPCNMTRYGKELSMVKIPSKASAKYLAKKFNKTEQYITDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVLKDKILGSVLRKRRPHRSASDNLVIVSLHDFKISSVFLLASYMCFVCYIVLLNAACVYLPFVVGSNSGK
PDB Structures
Ligand Binding
Binding Site
SITE 81: "Important for channel desensitizing"; SITE 289: "Important for channel gating"
Disease
Location
Expressed in central nervous system
DOI ID
10.1074/jbc.m401477200
RefSeq
NP_999954.1